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Carisoprodol is a centrally acting muscle relaxer with a trajectory of more than 20 years in the market. It is indicated to calm the pain caused by injuries in the musculoskeletal apparatus. Currently, you can get carisoprodol online at cheaper prices and without having to go out of your home.

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The actions of carisoprodol are related to a central mechanism (ie, CNS) and not to a direct effect on skeletal muscle. Carisoprodol acts by disrupting neural communication within the reticular formation and spinal cord. CNS depression produces sedation, and the perception of pain can be altered. Some authors estimate that most of the benefits observed with carisoprodol are secondary to a generalized sedative effect, but this is difficult to verify because of the limited amount of clinical data available.

 

Carisoprodol induces hepatic microsomal enzymes. Carisoprodol is given orally. After oral administration, the onset of action occurs in approximately 30 minutes and lasts for 4-6 hours. Carisoprodol distributes widely in the body, crosses the placenta and is excreted in breast milk. At hepatic level, carisoprodol is metabolized to several metabolites including meprobamate, but it is not clear whether any of these metabolites contribute to the clinical response. The plasma half-life is about 8 hours. It is excreted mainly by the urine in the form of metabolites.

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As regards the toxicity of carisoprodol, no long-term studies have been carried out to determine the carcinogenic potential of carisoprolol. Only some animal tests were carried out to evaluate these parameters. In some studies, carisoprodol was mutagenic in the mouse lymphoma cell test in vitro and in the chromosome aberration test with Chinese hamster ovary cells. But, on the other hand, it was not mutagenic in the Ames test or in the micronucleus assay in the mouse.


In the mouse, carisoprodol did not alter fertility, although the doses of 1200 mg / kg / day caused alterations in reproductive cycles with a longer estrus duration in females and a reduction in testis weight and motility Of spermatozoa in males.


There are no known drug interactions with carisoprodol, but additive CNS depression is possible if used concomitantly with other depressants such as anxiolytics, sedatives and hypnotics, benzodiazepines, barbiturates, butorphanol, nalbuphine, opioid agonists, pentazocine, tramadol, antidepressants tricyclics, phenothiazines, ethanol, or H1-blockers. Dosage adjustments of one or both medications may be necessary.

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The phytomedicinal herbs valerian, Valeriana officinalis or kava kava, Piper methysticum can also interact in this way. There may be additive effects of sedation and dizziness, effects that may affect the ability to perform tasks that require mental alertness.


Many of the muscle aches for which carisoprodol is indicated are caused by muscle cramps. When you experience a muscle cramp, the pain is intense and sudden. The cause may be a lack of magnesium. The lack of magnesium is Associated with an intense physical effort, for example when practicing a sport, the sweat causes the loss of magnesium. If muscle cramps are frequent, other diseases can be the cause, for example, liver disease.


Muscle pain (myalgias) can be caused by very different causes. Often, it is due to muscle stiffness (miogelosis) or muscle injury. Other less frequent triggers of muscle pain are bone (skeletal) diseases, joint wear (osteoarthritis), muscle or nervous system diseases.

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Muscle pains (myalgias) frequently occur in the context of muscular tension (myelos- sis). The state of tension (toning) of the muscle is increased; the shortened muscle is hard palpated. This condition is also called muscle induration. The muscles or groups of affected muscles can be felt as small lumps or protrusions that cannot be completely undone by massage. Occasionally, permanent muscle tension can lead to headache.


The most frequent causes of muscular tensions are: stress, incorrect body positions and lack of movement. It is known that sitting in front of the computer or in the car for too long and with poor posture can cause overloading of muscles as well as chronic inadequate body postures, especially in the back (back pain). The area of the shoulders and the back of the neck can also be affected, which are the points where the pains of the accumulated tension are most commonly experienced. In turn, the wrong movements can lead to tension and muscle cramps. Insufficient toning of muscles and unbalanced relationship between different groups of muscles (eg between the abdominal and lumbar muscles), which leads to inadequate body postures and incorrect loading of muscles (especially of the spine). Muscle injuries (muscle pull, fibrillar tear, muscle tear), preliminary warm-up, and insufficient posterior stretching when playing sports.

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Carisoprodol has provided guarantees to alleviate the pains of all these different ailments, thanks to its mechanism of action. It may also be used in combination with other drugs. A specific case is its administration together with an anti-inflammatory such as naproxen which ensures good analgesic efficacy. One study aimed to evaluate the joint administration of both drugs in a group of athletes. The subjects studied presented several musculoskeletal pathologies that were at a fairly advanced stage. Patients were divided into two groups: one was given carisoprodol + naproxen, while the other group was assigned N-acetyl-p-aminophenol + methocarbamol. The treatment given to each patient was administered every 6 hours for three days, with periodic evaluations of the usual measurements in this type of study. The association of carisoprodol plus naproxen showed greater therapeutic efficacy in the indices evaluated compared to the treatment with N-acetyl-p-aminophenol + metocarbamol.


In conclusion, carisoprodol is an excellent option to get rid of the pains, contractures, cramps and stresses that can often afflict a person. In addition the medication could provide a momentary sense of well-being that will help carry out the daily tasks.